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ea0041gp220 | Thyroid Cancer | ECE2016

Genomic alterations of anaplastic thyroid carcinoma detected by targeted massive parallel sequencing of a BRAFV600E mutation-prevalent area

Chung Yun Jae , Jeon Min Ji , Chung Sung Min , Kim Deokhoon , Kwon Hyemi , Kim Won Gu , Shong Young Kee , Song Dong Eun , Kim Won Bae

Background: Anaplastic thyroid carcinoma (ATC) is the most aggressive type of thyroid cancer and has no effective therapy. Due to its dismal prognosis, it is vital to understand the genetic alterations of ATC and identify effective molecular targets. We performed targeted next-generation sequencing to investigate the mutational profile of ATC using a massive parallel sequencing approach.Methods: DNA from formalin-fixed, paraffin-embedded archival samples...

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ePoster

ea0073pep5.8 | Presented ePosters 5: Thyroid | ECE2021

Genetic profiles of aggressive variants of papillary thyroid carcinomas

Jin Meihua , Song Dong Eun , Ahn Jonghwa , Song Eyun , Yu-Mi Lee , Tae-Yon Sung , Kim Tae Yong , Kim Won Bae , Shong Young Kee , Jeon Min Ji , Gu Kim Won

BackgroundAggressive variants of papillary thyroid carcinoma (PTC) have been described with increasing frequency and are associated with unfavorable clinical outcomes. However, limited data exists on the comprehensive genetic profile of these variants.MethodWe performed targeted next generation sequencing in 36 patients with aggressive variants of PTC and compared it to PTC from The Cancer Genome Atlas projec...

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Endocrine Abstracts

Genomic alterations of anaplastic thyroid carcinoma detected by targeted massive parallel sequencing of a BRAFV600E mutation-prevalent area

Genetic profiles of aggressive variants of papillary thyroid carcinomas

BiosciAbstracts